![]() This invasion is adaptive as it is triggered by environmental fluctuations. Using lineage labeling, in vivo time lapse imaging and scRNA-seq, we discovered highly motile skin-derived cells that invade mature mechanosensory organs of the zebrafish lateral line and differentiate into Neuromast-associated (Nm) ionocytes. In contrast, fish lateral line HCs are exposed to the fluctuating ionic composition of the aqueous environment. Actively-maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function. ![]() Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals.
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